The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic formation. In recent decades, their key role has broadly expanded beyond physiology and pathology. Nowadays, BMP pathway is considered an important player vascular signaling. Indeed, mutations genes encoding different of cause various severe diseases. Their signaling contributes to morphological, functional molecular heterogeneity among endothelial cells vessel types such arteries, veins, lymphatic vessels capillaries within organs. The a remarkably fine-tuned pathway. As result, its output wall critically depends on cellular context, which includes flow hemodynamics, interplay with other cascades interaction peri-endothelial surrounding matrix. this review, emerging biology will be highlighted framework circulatory vasculature.